However, the K121E mutation was shown to destabilize A3H Hap I in cells and supported the conclusion that the loss of A3H Hap I activity through the K121E variant may benefit the cancer and be detrimental to the host, suggesting that A3H Hap I deamination activity can induce tumour cell death or immune recognition [174]. The gene discussed is APOBEC3H; the disease is neoplasm.