Apolipoprotein E deficiency in ApoE–/– mice seems to be strongly correlated with MAFLD development and plays an important role in metabolic syndrome [17,44,45], as the absence of ApoE spontaneously induces hypercholesterolemia, obesity and atherosclerosis [17,19]. Here, APOE is linked to hyperinsulinemic hypoglycemia, familial, 4.