Our finding of a homozygous, candidate-causative variant in COL7A1 likely leading to a lack of collagen VII production in all three puppies is compatible with DEB, as this gene has multiple documented variants known to cause human DEB [1,2,3,4,5,6,7,8], and is found in two other canine cases of DEB [14,15,16]. This evidence concerns the gene COL7A1 and Dystrophic epidermolysis bullosa.