However, in this study, it was observed that both the treatment with diazoxide, the exercise protocol, and the combination of both decreased bodyweight and plasma glycemia during obesity, effects that may be related to the reduction in the consumption of food, improvement of basal metabolic rate, reduction of lipogenesis, improvement of insulin sensitivity and glucose transport, and suppression of hyperinsulinemia [5,17,22,33]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.