MUC16 and ovarian neoplasm: The hybrid SVM model based on CA125 and five plasma putative metabolites for distinguishing benign and malignant (borderline + malignant) ovarian tumors showed a higher diagnostic performance than that of CA125 alone (AUC: 0.972 versus 0.882, 0.932 versus 0.903, in discovery and validation cohorts respectively) (Figure 4b,e).