Of note, fucoidans also showed bioactivities that may be protective in diabetes outside the eye, such as the inhibition of dipeptidyl peptidase-IV (DPP-IV), the inhibition of starch hydrolyzing enzymes, and improving insulin-stimulated glucose uptake, thereby protecting the retina by conferring anti-hyperglycemic effects [81,82,83]. The gene discussed is DPP4; the disease is diabetes mellitus.