In ALK resistant neuroblastoma cells, BORIS can induce the formation of new super-enhancers that drive the expression of a group of pro-neural transcription factors, including neurogenic differentiation 1 and 2, SRY-box 2 and 9 and Achaete-scute complex homolog 2, promoting a phenotypic switch in resistant cells [60]. Here, ALK is linked to neuroblastoma.