TRPM7 and perinatal asphyxia: Also, it has been demonstrated that TRPM7 mediates neuronal cell death during neonatal hypoxic-ischemic brain injury, a model of hypoxic-ischemic encephalopathy, by the regulation of calcium/calmodulin-dependent protein kinase II, calcineurin p38 and cofilin cascade, where the inhibition of TRPM7 using waixenicin A reduces brain injury and improves the short- and long-term functional outcomes [373].