TRPM7 but no TRPM6 expression, it is also important in the predisposition of patients with inflammatory bowel disease to colorectal cancer (CRC) and the progression of CRC, where it has been shown that TRPM7 expression is related to tumor infiltration, lymph node metastasis, distant metastasis and advanced clinical stage in patients [360,361]. This evidence concerns the gene TRPM7 and colorectal carcinoma.