We recently demonstrated that the role of TRPM7 in the progression of endotoxemia is that the channel expression and activity increase the secretion of pro-inflammatory cytokines like tumor necrosis factor-a (TNF-α), IL-1β, IL-6 and IL-12 without changing the anti-inflammatory cytokine production. The gene discussed is TRPM7; the disease is serum lipopolysaccharide activity.