TRPM6 disorders have also been associated with clinical complications derived from chronic diseases such as diabetes [354,355], where TRPM6 V1393I and TRPM6 K1584E polymorphisms present in pregnant women with insulin resistance generate high susceptibility to developing gestational diabetes mellitus or diabetes mellitus type 2, possibly by the underlying defects in Mg2+ transport that affect insulin receptor sensitivity [315]. This evidence concerns the gene TRPM6 and Insulin resistance.