Several studies of prostate cancer cells have shown that the Ca2+/Mg2+ ratio has an important role in the initiation and progression of this type of cancer, added to the importance of hypoxia in TRPM7 activity and its role in the epithelial-mesenchymal transition and cell migration of cancer cells due to TRPM7-HIF-1α-Anexin-1 signaling axis activation [358,359]. This evidence concerns the gene TRPM7 and Familial prostate cancer.