In another report stressing the role of exosome-regulated inflammation in melanoma, it was stated that melanoma exosomes determine endothelial tubule morphology and induce endothelial spheroid production, while simultaneously eliciting paracrine endothelial cell signaling by upregulation of certain cytokines (e.g., L-1α, FGF, GCS-F, TNF-α) involved in tumor-associated inflammation [113]. This evidence concerns the gene TNF and melanoma.