MAPK3 and bullous pemphigoid: Bullous pemphigoid is an autoimmune inflammatory disorder associated with dermal- blister formation and recently Fang et al. observed that exosomes from blister fluids of patients with bullous pemphigoid, play critical role in its pathogenesis by inducing inflammatory response due to over production of cytokines and chemokines via modulating ERK1/2 and STAT3 signaling [184].