CCL2 and melanoma: Marton et al. [115] studied the inflammatory and immunomodulatory effect of exosomes deriving from melanoma cells, and quantified the activation of NF-κB as well as production of cytokines (IFN-γ and IL-16) and chemokines (IL-8, and MCP-1 or CCL2) involved in inflammation and maturation of macrophages.