For example, melanoma derived exosomes exert anti-tumor effects by transferring tumor antigens from cancer cells to dendritic cells, thereby inducing CD8+ T-cell dependent anti-tumor effects in human melanoma cells ex vivo and in mouse as well as when exosomes are fused with bone marrow-derived myeloid precursor cells (CD11b+Gr-1+) and injected into mice with established melanoma [38,104]. This evidence concerns the gene CD8A and melanoma.