Along that line, Jiang et al. [128] demonstrated that exosomes, isolated from psoriasis-like keratinocytes and treated with a ‘psoriatic cytokine cocktail’ (involving IL-17A, IL-22, and TNF-a), are critical players in the induction of psoriatic inflammation, due to T-cell and neutrophil activation and infiltration. The gene discussed is TNF; the disease is psoriasis.