Notably, treatment of CCR1-positive MM cell lines with the CCR1 ligand C-C chemokine ligand 3 (CCL3; also known as macrophage inflammatory protein 1 alpha [MIP-1 α]) abrogates migration towards CXCL12 in vitro, suggesting that CCL3/CCR1 signalling can desensitise cells to exogenous CXCL12 [35]. This evidence concerns the gene CCL3 and Miyoshi myopathy.