In a study utilising whole exome sequencing of paired BM and PB tumour samples from 4 patients, Manier et al. identified one patient with 17p loss across the BM and PB sample with a TP53 missense mutation which was only detectable in the PB sample, suggesting a potential association between loss of p53 function and increased the propensity for dissemination [129]. Here, TP53 is linked to neoplasm.