This indicates that neither GHR nor IGF-1R expression appears to be a determinant of overall mortality in melanoma patients in the TCGA cohort (Figure S7), though they may influence treatment response and outcome, as the expression of several EMT mediators and ABC transporters were upregulated in the TCGA dataset irrespective of the heterogeneity in treatment patterns (Figure S8). This evidence concerns the gene IGF1R and melanoma.