Additive stimulation by Omega-3 and TZDs, with a stronger effect of HF + MSDC + F, was observed in both eWAT and scWAT, as documented by the expression of the genes involved in FA uptake (Lpl and Cd36), lipolysis (Atgl/Pnpla2 and Hsl/Lipe), glyceroneogenesis (Pc/Pcx and Pck1), FA re-esterification (Dgat1) and FA oxidation (Crat, Vlcd/Acadlv and Acsl1), and the biochemical data. This evidence concerns the gene PNPLA2 and hydrops fetalis.