SOD2 and Wilson disease: Based on the obtained results, the following conclusions were drawn: (i) in WD, the effectiveness of antioxidant mechanisms is decreased; (ii) therapy to reduce copper overload improves the antioxidant status of patients but does not normalize it; (iii) the efficiency of antioxidant protection increases after the application of the therapy, probably as a result of an increase in the content of low molecular weight antioxidants; (iv) D-penicillamine may reduce GPx activity; and (v) decreasing Mn-SOD and GPx activities may be associated with neuropsychiatric presentation of WD [208].