FLT3 and acute myeloid leukemia: The latter is an FDA approved kinase inhibitor for the treatment of adult patients with newly diagnosed, FMS-like tyrosine kinase 3 (FLT3) mutation-positive acute myeloid leukemia in combination with standard cytarabine and daunorubicin induction, and cytarabine consolidation, or with aggressive systemic mastocytosis, systemic mastocytosis with associated hematological neoplasm or mast cell leukemia.