Utilizing the xCell algorithm [24], we found that pancreatic cancer with a high four-gene score was significantly associated with a lower fraction of CD8+ T cells consistently in the TCGA, GSE62452, and GSE57495 cohorts (Figure 5A; p = 0.037 and 0.002, and p < 0.001, respectively). Here, CD8A is linked to familial pancreatic carcinoma.