The causes of this different modulation of Adiponectin in immunodeficiencies and autoimmune diseases and the different anti or pro-inflammatory actions of Adiponectin are not yet totally clear [8]; the explanation is that, in addition to the different types of immune cells and mechanisms that intervene in immunodeficiencies compared to the autoimmune diseases, different Adiponectin isoforms intervene [7,11,12,13,14]. This evidence concerns the gene ADIPOQ and immunodeficiency disease.