In studies conducted on intestinal IgA plasmablasts isolated from patients with ascending colon cancer, Benckert et al. (2011) observed that about half of IgA clones do not react with a panel of commensal and pathogenic microbial strains, third of the clones were cross-species reactive, fifth were self-reactive and the small fraction of clones reacted with single target of prepared panel of microbial strains [24,48]. The gene discussed is CD79A; the disease is malignant colon neoplasm.