They can induce the dedifferentiation process of the epithelial component of cancer cells by repressing the transcription of epithelial gene transcription such as E-cadherin, known as a classic epithelial expressing gene; and activating mesenchymal gene such as N-cadherin as a classic mesenchymal expressing gene [37,38] However, we did not analyze all EMT-TFs; therefore, our results cannot reflect all the possible mechanisms of epigenetic regulation of EMT in lung adenocarcinomas. The gene discussed is CDH2; the disease is lung adenocarcinoma.