Although unique histone lysine modification enzymes did not influence the survival of patients directly, several enzymes such as MLL4 (H3K4 methyltransferase), UTX (H3K27me3 demethylase), and EZH2 (H3K27 methyltransferase) regulate the expression of specific EMT-TFs; these EMT-TFs are associated with survival of patients with lung adenocarcinoma via epigenetic regulation. This evidence concerns the gene KDM6A and lung adenocarcinoma.