In fact, the production of monocyte chemoattractant protein-1 (MCP-1), as well as other inflammatory chemokines produced by the tumor, induce mobilization of M-MDSC into the TME, where they differentiate into immunosuppressive TAM, which have the potential to further suppress anti-tumor immune responses in PC [8,12,13,14]. This evidence concerns the gene CCL2 and neoplasm.