Even though further study is required to evaluate the delivery of LNPs in orthotopic models of colon cancer in terms of the delivery mechanisms of LNPs in the peritoneal compartment and the efficacy of their cargos, the combination of PD-1/PD-L1 blockade with siVegfr2 delivery by the LNP system could be applicable for the treatment of peritoneal disseminations. The gene discussed is CD274; the disease is colonic neoplasm.