In addition of the important role of VIP during states of polarization, differentiation or activation from Th cells in healthy conditions or early arthritis conditions, our results show that it could also have consequences on the senescence of these cells, increasing the expression of CD27 and decreasing the expression of CD57 and NKG2D in of CD4+CD28− T cells after 7 days of culture, trying to counteract the senescence in these cells. Here, CD28 is linked to Arthritis.