Liu and colleagues [99] also provided in vivo evidence, using an AML mouse model, that the overexpression of miR-125b can cooperate with MLL-AF9 (mixed-lineage leukemia (MLL) fused to the ALL1-fused gene from chromosome 9 (AF9)), a fusion protein associated with AML. This evidence concerns the gene KMT2A and acute myeloid leukemia.