Another lncRNA, ANRIL (anti-sense non-coding RNA in the INK locus), can interact with PRC1 and PRC2 complexes to repress gene transcription, including tumor-suppressor genes such as the p15/CDKN2B, p16/CDKN2B and p14ARF gene clusters [71,72]. This evidence concerns the gene CDKN2B and neoplasm.