AKT1 and colorectal carcinoma: Mechanistically, HOXD1-AS1 can suppress the growth of colorectal carcinomas and metastasis by inhibiting MAPK/AKT signaling (a crucial pathway involved in cell proliferation) and the HOXD3-mediated transcriptional activation of integrin ß3, which initiates MAPK/AKT signaling [178].