In connection with reduced invasion after ARHGAP29 knock-down, this indicates a relevant role of ARHGAP29 regarding the invasion of mesenchymal-transformed and invasive breast cancer cells, which can be achieved by favoring a flexible cytoskeleton caused by RhoA suppression but also by less adhesive, more motile cells [8,30,32]. The gene discussed is ARHGAP29; the disease is breast carcinoma.