MMP8 and Peri-Implantitis: Thus, we suggest that in future studies of peri-implantitis, patients should be analyzed for well-established biomarkers of systemic inflammation (for example, high sensitivity C-reactive protein (hsCRP), cytokines such as interleukin (IL)-6, and collagenolytic enzymes such as MMP-8, MMP-9) in their blood samples, before and after local debridement procedures, and in combination with HMT.