In hepatocellular carcinoma, MDR1 (multidrug resistance 1) and GST-π (glutathione S-transferase-π) high protein expression levels were detected in CD133+ CSCs, in association with an overexpression of H19. In these cell lines, H19 has been shown to affect the degree of oxidative stress by reducing the reactive oxygen species (ROS) production. The gene discussed is H19; the disease is hepatocellular carcinoma.