H19 and pancreatic ductal adenocarcinoma: At the transcriptional regulation level, H19 can activate transcription factors like E2F1 in pancreatic ductal adenocarcinoma, leading to increased cell proliferation [46]; H19 can also interact with the PRC2 complex to recruit it to its target genes promoters, leading to the modulation of chromatin condensation and the inaccessibility of gene promoters to transcription factors [47].