GSTP1 and hepatocellular carcinoma: In hepatocellular carcinoma, MDR1 (multidrug resistance 1) and GST-π (glutathione S-transferase-π) high protein expression levels were detected in CD133+ CSCs, in association with an overexpression of H19. In these cell lines, H19 has been shown to affect the degree of oxidative stress by reducing the reactive oxygen species (ROS) production.