Of interest, the above described loop regulation between H19 and LIN28 in the promotion of CSCs symmetric division is also involved in reprogramming: indeed, in patient lung cancer samples, there exists a positive correlation between H19 and LIN28 expressions, and further analysis showed an increase of LIN28 expression by H19. This is due to the sponging of miR-196b by H19, that normally supresses LIN28 mRNA translation. Here, LIN28A is linked to lung cancer.