The changes in MMP2 activity and expression levels with myopia induction and LF administration were consistent with this IL-6 expression pattern, and IL-6 is a positive regulator of MMP-2 expression [25,26], suggesting that LF suppresses the activation of MMP-2 by myopia induction through its anti-inflammatory effects, including IL-6 expression. The gene discussed is IL6; the disease is myopia.