Finally, different long non-coding RNAs (lnc-RNAs) have been shown to be downstream effectors of canonical TGF-β/Smad2-3-4 signaling mediated tumor cell-CAF crosstalk with implications in the growth and metastasis of breast [33,34,53], bladder [54] and oral carcinomas [55]. This evidence concerns the gene TGFB1 and neoplasm.