Joseph et al. [69] have reiterated that nine IFN-related genes, including MX, IFI44L, PARP9, DT3XL, IFIT1, IFI44, RSAD2, PLSCR1, and IRF7 are implicated in type I IFN pathway activation, and thus are relevant to the disease activity of SLE (SLEDAI). The gene discussed is IRF7; the disease is systemic lupus erythematosus.