It is worthy to note that some of the same cell-free lncRNAs may be implicated in different autoimmune or rheumatic inflammatory diseases, among which a decreased expression of lncRNA growth arrest-specific 5 (GAS5) has been found in SLE, pediatric inflammatory bowel disease [124,125], and rheumatoid arthritis [126]. This evidence concerns the gene GAS5 and systemic lupus erythematosus.