PAK1 and glioblastoma: To study whether the selective blockade of a single endocytic pathway (CME, CVME or macropinocytosis) could lead to a marked decrease in AMC6-mediated FAM-siRNA uptake, we treated T98G glioblastoma cells with nanoplexes formed by AMC6 and siRNA, either SCR or aimed to knockdown CLTC, CAV1 or PAK1, for 48 h.