In order to enhance the target ability, HA was functionalized with HRK-19, a peptide containing RGD and NGR (Asn–Gly–Arg) motifs able to bind αvβ3 and aminopeptidase-N (CD13) receptors overexpressed in glioma cells and/or angiogenic vessels [41]. The gene discussed is ANPEP; the disease is central nervous system cancer.