We also analyzed the associations of CCDC170, IRE1 and XBP1 mRNA levels with clinicopathologic characteristics such as ERα, progesterone receptor (PR), Her2 and Ki67 levels, the PAM50 subtype, tumor size, lymph node status and TNM stage in TCGA (Supplementary Figures 3D, 3E, 4A–4R) and GEO (Supplementary Figure 2A–2R). Here, XBP1 is linked to neoplasm.