Indeed, an increased accumulation of PF-Pink1 was detected from the cells with an overexpression of Bag2 along with Fbxo7 or its PD familial mutants when compared to the control cells with only an overexpression of Fbxo7 or its PD familial mutants (Pink1 western blot for total cell lysates in Figure 3). The gene discussed is FBXO7; the disease is Parkinson disease.