PRKN and Parkinson disease: The symptoms caused by Fbxo7 mutations are similar to those caused by Pink1 (PTEN-induced putative kinase 1; PARK6) or Parkin (RBR E3 ubiquitin-protein ligase; PARK2) mutations [8–10], suggesting that the crosstalk of these three genes plays an essential role in the pathogenesis of PD.