FOXM1 bound to DVL2 and facilitated nuclear translocation of DVL2 to promote DVL2-mediated transcriptional activity, Snail expression, and induced EMT-like molecular changes and multidrug-resistance protein P-gp expression which are simultaneously executed by Snail, resulting in both metastasis and chemoresistance in CRC cells. This evidence concerns the gene FOXM1 and colorectal carcinoma.