FXR was activated and BRD4 was inhibited by daily treatment with OCA and JQ1, respectively, for 7 days, and then in addition for the last 2 days with α-naphthylisothiocyanate (ANIT), which induces intrahepatic cholestasis by damaging biliary epithelial cells (5, 40–43) (Figure 4A). The gene discussed is NR1H4; the disease is intrahepatic cholestasis.