BRCA1 and chronic obstructive pulmonary disease: We found BRCA1 AQUA score inversely correlated with miR-24-3p expression (P = –0.813, P < 0.0001) (Figure 7D), and we found increased BRCA1 in cytokeratin-positive nuclei from COPD lung tissue samples compared with non-COPD samples (1.76-fold, P < 0.0001) (Figure 7E).