In order to verify that hsa_circ_0079480 exhibits an oncogenic influence on AML progression by modulating miR-654-3p/HDGF pathway, miR-654-3p inhibitor or HDGF overexpression plasmid (HDGF) was co-transfected using si-circ0079480 (si-circRNA). This evidence concerns the gene HDGF and acute myeloid leukemia.