CD31, TGF-β1, ALK-1, Smad1/5 and p-Smad1/5 levels in the penumbra of the ischemic brain were elevated at 7 and 14 days after stroke, and this increase was significantly improved by Coicis Semen administration (P < 0.05, Figure 6). The gene discussed is ACVRL1; the disease is stroke disorder.