We repeated these experiments using the human Siglec receptors: (i) CD33, which is implicated in AD GWAS studies (Karch & Goate, 2014); (ii) Siglec‐5, which has the closest sequence homology to Siglec‐F; (iii) Siglec‐8, which has the closest substrate binding pattern to Siglec‐F (preferring 6’‐sulfo sialyl Lewis x; O’Sullivan et al, 2018). The gene discussed is CD33; the disease is Alzheimer disease.