Furthermore, among men with overt hypogonadism, secondary (including normogonadotropic) form was the most frequently observed, with a prevalence of 75%, in substantial agreement with literature [6], thus suggesting that these alterations may be due to a hypothalamic–pituitary–gonadal axis dysfunction, with an inadequate pituitary gland response to SHBG elevation. Here, SHBG is linked to hypogonadism.