PLOD1 and hypogonadism: If we had used TT alone as diagnostic criterium in these patients, as we did in Group A, only 10 out of 94 (10.6%) would have met hypogonadism diagnosis, a prevalence close to what we actually found in Group A. The addition of cFT has, therefore, allowed us to diagnose overt hypogonadism in 19 patients instead of 10, with an increase of 1.9 times; otherwise, these 9 patients with low cFT but normal TT would have been considered eugonadal or with compensated form, if considering TT alone or TT and LH.