Our findings showed that atorvastatin could increase the survival rate of tyrosine hydroxylase neurons and LC3 levels and decrease the protein expression of α-synuclein, which shows that atorvastatin's protective effect on PD mice may be related to LC3-mediated autophagy because enhanced autophagy can degrade α-synuclein and protect dopaminergic neurons. This evidence concerns the gene TH and Parkinson disease.