EDEM1 and periodontitis: The most positively correlated immunocyte-autophagy gene pair is EDEM1-Activated B cell, and a higher expression of EDEM1 and a higher score of Activated B cell were found in periodontitis (Figure 3C); while the most negatively correlated pair is NCKAP1-Monocyte, and a lower expression of NCKAP1 and a higher level of Monocyte population could be found in periodontitis (Figure 3D).