For HLA, the most positively correlated HLA-autophagy pair is EDEM1-HLADOB, and a higher expression of EDEM1 and HLA-DOB was observed in periodontitis (Figure 5C); while the most negatively correlated pair is RAB11A-HLADOB, indicating a lower expression of RAB11A and a higher expression of HLA-DOB could be observed in periodontitis (Figure 5D). Here, HLA-DOB is linked to periodontitis.