PPARA and malaria: The result in Table 3 showed that several signaling pathways were involved in the down regulation of UC associated mRNAs, including PPAR, fatty acid degradation, drug metabolism – cytochrome P450, glycerolipid metabolism, tyrosine metabolism, complement, and coagulation cascades, retinol metabolism, glycolysis/gluconeogenesis, glycine, serine and threonine metabolism, and malaria (P < 0.001 for each pathway).