The results showed that high AFP levels (AFP > 8 ng/ml) combined with a high ALT level (ALT > 2 ULN) could significantly enhance the prediction of liver fibrosis (OR = 11.968; 95% CI: 2.723–52.609; P=0.001, Table 4) and high AFP level (AFP > 8 ng/ml) combined with high AST level (AST > 2 ULN) also significantly enhanced the predictive performance of liver fibrosis (OR = 28.261; 95% CI: 3.792–210.596; P=0.001, Table 4). This evidence concerns the gene GPT and Hepatic fibrosis.