IRS2 and Insulin resistance: Transcripts shown to be predicative of hepatic insulin resistance (follistatin [Fst], inhibin subunit beta E [Inhbe], insulin receptor substrate 2 [Irs2]) (Tao et al., 2018; Parks et al., 2015) and gluconeogenic plasticity (phosphoenolpyruvate carboxykinase 1 [Pck1], pyruvate kinase [Pkm]) (Xiong et al., 2011) were also beneficially modulated by 17α-E2 in male WT mice (Figure 4—figure supplement 1).