SPI1 and leukemia: By contrast to the downregulation of HOX genes and CDK6 gene expression, further RNA expression analysis showed a three‐fold upregulation of CEBPE at the mRNA level in the leukemia cell line MV4‐11, whereas the expression of additional myeloid differentiation marker CEBPA and PU.1 was not affected by JDM‐7 (Fig. 3D).