Accordingly, it has been demonstrated in a recent study that LUBAC and OTULIN also play important pro-survival roles in the recognition and processing of misfolded proteins associated with neurodegenerative diseases, such as mutated Huntingtin, superoxide dismutase 1 (SOD1) and TAR DNA-binding protein 43 (TDP-43) [38]. The gene discussed is SOD1; the disease is neurodegenerative disease.