Furthermore, cell death may contribute to the ORAS pathophysiology as well, since apoptotic cell death could be detected in the skin of an ORAS patient during ORAS-dependent inflammation and patient-derived OTULIN-deficient fibroblasts are sensitized to TNFα/CHX-induced apoptosis [7]. The gene discussed is OTULIN; the disease is autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive.