For DKC1, the enzymatically active component of the H/ACA box snoRNP complex, there was a significant correlation between high DKC1 mRNA levels and poor overall survival of NSCLC patients (median 59 (52) months vs. 77.6 (80.9) months, Supplementary Fig. 2c, d). Here, DKC1 is linked to non-small cell lung carcinoma.