INS and pancreatic insulinoma: While the vast majority of β-like PanNETs expressed PDX1 and insulin, the two malignant (N1 and/or M1) insulinomas of our cohort, showed one intermediate-ADM (DAXX/ATRX mutated) and one α-like (DAXX/ATRX wild-type) methylation signatures (Supplementary Data 1).