The ABC subtype has been linked to mutations in CD79A/B, CARD11, MYD88, and TNFAIP3 (A20)2,6, whereas the GCB subtype has been linked to mutations in KMT2D (MLL2), CREBBP, GNA13, and EZH2Y646F7–10. This evidence concerns the gene KMT2D and aneurysmal bone cyst.