AJCC T2/T3/T4 (hazard ratio [HR] = 1.280/2.221/3.352, P < 0.01), AJCC M1 (HR = 2.540, P < 0.001), tumor resection (HR = 0.363, P < 0.001), liver transplantation (HR = 0.096, P < 0.001), grade II/III/IV (HR = 1.234/1.998/2.214, P < 0.05), elevated AFP level (HR = 1.336, P < 0.001) and cirrhosis (HR = 1.356, P < 0.001) were all significantly associated with CSS in HCC patients (Table 2). This evidence concerns the gene AFP and Cirrhosis.